PDBe 5yv8

X-ray diffraction
1.93Å resolution

Structure of CaMKK2-inhibitor complex

Source organism: Homo sapiens
Entry authors: Niwa H, Handa N, Yokoyama S

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Calcium/calmodulin-dependent protein kinase kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 298 amino acids
Theoretical weight: 33.71 KDa
Source organism: Homo sapiens
Expression system: unidentified
  • Canonical: Q96RR4 (Residues: 158-448; Coverage: 50%)
Gene names: CAMKK2, CAMKKB, KIAA0787
Sequence domains: Protein kinase domain

Ligands and Environments

3 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL26B2
Spacegroup: P212121
Unit cell:
a: 66.493Å b: 76.969Å c: 83.895Å
α: 90° β: 90° γ: 90°
R R work R free
0.166 0.164 0.213
Expression system: unidentified