PDBe 5yke

Electron Microscopy
4.11Å resolution

Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (focused refinement on TM at 4.11A)


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
ATP-sensitive inward rectifier potassium channel 11 Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 390 amino acids
Theoretical weight: 43.62 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
  • Canonical: Q61743 (Residues: 1-390; Coverage: 100%)
Gene name: Kcnj11
Sequence domains:
ATP-binding cassette sub-family C member 8 isoform X2 Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 1582 amino acids
Theoretical weight: 177.3 KDa
Source organism: Mesocricetus auratus
Expression system: Homo sapiens
  • Canonical: A0A1U7R319 (Residues: 1-1582; Coverage: 100%)
Gene name: Abcc8
Sequence domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.11Å
Relevant EMDB volumes: EMD-6831
Expression system: Homo sapiens