PDBe 5xxy

X-ray diffraction
2.9Å resolution

Crystal structure of PD-L1 complexed with atezolizumab fab at 2.9A

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
heavy chain of atezolizumab fab Chain: H
Molecule details ›
Chain: H
Length: 240 amino acids
Theoretical weight: 25.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
light chain of atezolizumab fab Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.39 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Programmed cell death 1 ligand 1 Chain: A
Molecule details ›
Chain: A
Length: 124 amino acids
Theoretical weight: 14.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NZQ7 (Residues: 18-133; Coverage: 42%)
Gene names: B7H1, CD274, PDCD1L1, PDCD1LG1, PDL1
Sequence domains: Immunoglobulin V-set domain

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: C2
Unit cell:
a: 127.22Å b: 72.71Å c: 63.8Å
α: 90° β: 104.44° γ: 90°
R-values:
R R work R free
0.239 0.236 0.295
Expression systems:
  • Homo sapiens
  • Escherichia coli