5xr8

X-ray diffraction
2.95Å resolution

Crystal structure of the human CB1 in complex with agonist AM841

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cannabinoid receptor 1; Flavodoxin Chain: A
Molecule details ›
Chain: A
Length: 438 amino acids
Theoretical weight: 48.63 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: P00323 (Residues: 3-148; Coverage: 99%)
  • Canonical: P21554 (Residues: 99-306, 332-414; Coverage: 62%)
Gene names: CNR, CNR1, DVU_2680
Sequence domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Unit cell:
a: 66.83Å b: 73.61Å c: 139.64Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.256 0.255 0.274
Expression system: Homo sapiens