PDBe 5xj4

X-ray diffraction
2.3Å resolution

Complex structure of durvalumab-scFv/PD-L1

Released:
Source organism: Homo sapiens

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Programmed cell death 1 ligand 1 Chain: A
Molecule details ›
Chain: A
Length: 221 amino acids
Theoretical weight: 25.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NZQ7 (Residues: 19-238; Coverage: 81%)
Gene names: B7H1, CD274, PDCD1L1, PDCD1LG1, PDL1
Sequence domains:
durvalumab-VH Chain: H
Molecule details ›
Chain: H
Length: 121 amino acids
Theoretical weight: 13.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
durvalumab-VL Chain: L
Molecule details ›
Chain: L
Length: 114 amino acids
Theoretical weight: 12.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P23
Unit cell:
a: 133.89Å b: 133.89Å c: 133.89Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.216 0.24
Expression system: Escherichia coli