› 5xg8

X-ray diffraction
1.55Å resolution

Galectin-13/Placental Protein 13 variant R53H crystal structure

Released:
DOI: 10.2210/pdb5xg8/pdb
PDB entry 5xg8 coloured by chain, front view.
PDB entry 5xg8 coloured by chain, side view.
PDB entry 5xg8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Galectin-13, a different prototype galectin, does not bind β-galacto-sides and forms dimers via intermolecular disulfide bridges between Cys-136 and Cys-138.
Su J, Wang Y, Si Y, Gao J, Song C, Cui L, Wu R, Tai G, Zhou Y
Sci Rep 8 980 (2018)
PMID: 29343868

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193767 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Galactoside-binding soluble lectin 13 Chain: A
Molecule details ›
Chain: A
Length: 138 amino acids
Theoretical weight: 15.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UHV8 (Residues: 2-139; Coverage: 99%)
Gene names: LGALS13, PLAC8
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: C222
Unit cell:
a: 58.037Å b: 92.207Å c: 50.703Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.173 0.171 0.195
Expression system: Escherichia coli

Quick links

Citations

7 review citations

A Brief History of Charcot-Leyden Crystal Protein/Galectin-10 Research.
Su J. (2018)
6 more

2 mentions without citation

Galectin-13, a different prototype galectin, does not bind β-galacto-sides and forms dimers via intermolecular disulfide bridges between Cys-136 and Cys-138.
Su et al. (2018)
1 more