PDBe 5wh5

X-ray diffraction
1.8Å resolution

Crystal structure of the PDE4D2 catalytic domain in complex with inhibitor (R)-Zl-n-91

Source organism: Homo sapiens
Entry author: Wang H

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
cAMP-specific 3',5'-cyclic phosphodiesterase 4D Chains: A, B
Molecule details ›
Chains: A, B
Length: 327 amino acids
Theoretical weight: 37.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
  • Canonical: Q08499 (Residues: 388-714; Coverage: 40%)
Gene names: DPDE3, PDE4D
Sequence domains: 3'5'-cyclic nucleotide phosphodiesterase

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P212121
Unit cell:
a: 59.467Å b: 79.883Å c: 163.444Å
α: 90° β: 90° γ: 90°
R R work R free
0.194 0.193 0.214
Expression system: Escherichia coli BL21