PDBe 5w2i

X-ray diffraction
1.6Å resolution

Crystal structure of the core catalytic domain of human inositol phosphate multikinase soaked with C4-analogue of PtdIns(4,5)P2 and ADP


Function and Biology Details

Reaction catalysed:
(1a) ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Inositol polyphosphate multikinase Chain: A
Molecule details ›
Chain: A
Length: 257 amino acids
Theoretical weight: 29.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q8NFU5 (Residues: 50-262, 378-416; Coverage: 60%)
Gene names: IMPK, IPMK
Sequence domains: Inositol polyphosphate kinase

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P42212
Unit cell:
a: 78.09Å b: 78.09Å c: 86.32Å
α: 90° β: 90° γ: 90°
R R work R free
0.171 0.169 0.215
Expression system: Escherichia coli