X-ray diffraction
2.3Å resolution

Structure of human TUT7 catalytic module (CM) in complex with U5 RNA


Function and Biology Details

Reaction catalysed:
UTP + RNA(n) = diphosphate + RNA(n+1)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
Terminal uridylyltransferase 7 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 389 amino acids
Theoretical weight: 44.72 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: Q5VYS8 (Residues: 983-1365; Coverage: 26%)
Gene names: HS2, KIAA1711, TUT7, ZCCHC6
Sequence domains:
U5 single-stranded RNA Chains: H, I, J
Molecule details ›
Chains: H, I, J
Length: 5 nucleotides
Theoretical weight: 1.49 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P61
Unit cell:
a: 135.472Å b: 135.472Å c: 179.268Å
α: 90° β: 90° γ: 120°
R R work R free
0.19 0.188 0.229
Expression systems:
  • Spodoptera frugiperda
  • Not provided