X-ray diffraction
2.6Å resolution

Structure of apelin receptor in complex with agonist peptide


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
agonist peptide Chain: A
Molecule details ›
Chain: A
Length: 17 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
Expression system: Not provided
Apelin receptor; Rubredoxin Chain: B
Molecule details ›
Chain: B
Length: 407 amino acids
Theoretical weight: 46.44 KDa
Source organisms: Expression system: Spodoptera frugiperda
  • Canonical: P00268 (Residues: 1-54; Coverage: 100%)
  • Canonical: P35414 (Residues: 7-229, 243-330; Coverage: 82%)
Gene names: AGTRL1, APJ, APLNR
Sequence domains:

Ligands and Environments

2 bound ligands:

4 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: C2
Unit cell:
a: 150.58Å b: 44.3Å c: 79.45Å
α: 90° β: 114.87° γ: 90°
R R work R free
0.24 0.239 0.256
Expression systems:
  • Not provided
  • Spodoptera frugiperda