PDBe 5uyj

X-ray diffraction
1.6Å resolution

Crystal Structure of the Human CAMKK2B

Released:
Source organism: Homo sapiens
Entry authors: Counago RM, Drewry D, Arruda P, Edwards AM, Gileadi O, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium/calmodulin-dependent protein kinase kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 291 amino acids
Theoretical weight: 33.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96RR4 (Residues: 161-449; Coverage: 49%)
Gene names: CAMKK2, CAMKKB, KIAA0787
Sequence domains: Protein kinase domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P43212
Unit cell:
a: 73.153Å b: 73.153Å c: 120.305Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.154 0.153 0.171
Expression system: Escherichia coli BL21(DE3)