5uat

X-ray diffraction
1.92Å resolution

Structure of human PYCR-1 complexed with NADPH

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
homo decamer
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pyrroline-5-carboxylate reductase 1, mitochondrial Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 322 amino acids
Theoretical weight: 34.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P32322 (Residues: 1-300; Coverage: 94%)
Gene name: PYCR1
Sequence domains:

Ligands and Environments


Cofactor: Ligand NDP 2 x NDP
2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P21212
Unit cell:
a: 162.063Å b: 87.762Å c: 115.897Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.176 0.174 0.211
Expression system: Escherichia coli