PDBe 5twh

X-ray diffraction
2.5Å resolution

human MOB1A bound to MST1 phosphorylated T367 peptide

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
MOB kinase activator 1A Chain: A
Molecule details ›
Chain: A
Length: 216 amino acids
Theoretical weight: 25.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H8S9 (Residues: 1-216; Coverage: 100%)
Gene names: C2orf6, MOB1A, MOB4B, MOBK1B, MOBKL1B
Sequence domains: Mob1/phocein family
Serine/threonine-protein kinase 4 18kDa subunit Chain: E
Molecule details ›
Chain: E
Length: 17 amino acids
Theoretical weight: 1.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13043 (Residues: 358-374; Coverage: 4%)
Gene names: KRS2, MST1, STK4

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P43212
Unit cell:
a: 60.986Å b: 60.986Å c: 138.486Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.228 0.26
Expression system: Escherichia coli