› 5tv1

X-ray diffraction
2.4Å resolution

active arrestin-3 with inositol hexakisphosphate

Released:
DOI: 10.2210/pdb5tv1/pdb
PDB entry 5tv1 coloured by chain, front view.
PDB entry 5tv1 coloured by chain, side view.
PDB entry 5tv1 coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Structural basis of arrestin-3 activation and signaling.
Chen Q, Perry NA, Vishnivetskiy SA, Berndt S, Gilbert NC, Zhuo Y, Singh PK, Tholen J, Ohi MD, Gurevich EV, Brautigam CA, Klug CS, Gurevich VV, Iverson TM
OpenAccess logo Nat Commun 8 1427 (2017)
PMID: 29127291

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152207 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-arrestin-2 Chain: A
Molecule details ›
Chain: A
Length: 393 amino acids
Theoretical weight: 44.26 KDa
Source organism: Bos taurus
Expression system: Enterobacteria phage L1
UniProt:
  • Canonical: P32120 (Residues: 8-404; Coverage: 92%)
  • Best match: P32120-2 (Residues: 8-393)
Gene name: ARRB2
Sequence domains:
Structure domains: Immunoglobulin-like

Ligands and Environments

2 bound ligands:
Ligand IHP 2 x IHP
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P63
Unit cell:
a: 97.575Å b: 97.575Å c: 76.938Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.199 0.197 0.245
Expression system: Enterobacteria phage L1

Quick links

Citations

13 review citations

Structure and dynamics of GPCR signaling complexes.
Hilger et al. (2018)
12 more

22 mentions without citation

Structural Basis of Arrestin-Dependent Signal Transduction.
Chen et al. (2018)
21 more