5tpz

X-ray diffraction
3.1Å resolution

Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2B in apo closed state

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Glutamate receptor ionotropic, NMDA 1 Chain: A
Molecule details ›
Chain: A
Length: 383 amino acids
Theoretical weight: 42.93 KDa
Source organism: Xenopus laevis
Expression system: Trichoplusia ni
UniProt: Gene name: grin1
Sequence domains: Receptor family ligand binding region
Structure domains: Rossmann fold
Glutamate receptor ionotropic, NMDA 2B Chain: D
Molecule details ›
Chain: D
Length: 362 amino acids
Theoretical weight: 41.15 KDa
Source organism: Rattus norvegicus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q00960 (Residues: 32-393; Coverage: 25%)
Gene name: Grin2b
Sequence domains: Receptor family ligand binding region
Structure domains: Rossmann fold

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P6122
Unit cell:
a: 75.782Å b: 75.782Å c: 548.556Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.244 0.24 0.3
Expression system: Trichoplusia ni