X-ray diffraction
1.7Å resolution

Desmethyl-4-deoxygadusol synthase from Anabaena variabilis (Ava_3858) with NAD+ and Zn2+ bound


Function and Biology Details

Reaction catalysed:
D-sedoheptulose 7-phosphate = demethyl-4-deoxygadusol + phosphate + H(2)O
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Demethyl-4-deoxygadusol synthase Chains: A, B
Molecule details ›
Chains: A, B
Length: 444 amino acids
Theoretical weight: 50.13 KDa
Source organism: Trichormus variabilis ATCC 29413
Expression system: Escherichia coli
  • Canonical: Q3M6C3 (Residues: 1-410; Coverage: 100%)
Gene name: Ava_3858
Sequence domains: 3-dehydroquinate synthase
Structure domains:

Ligands and Environments

Cofactor: Ligand NAD 2 x NAD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: P212121
Unit cell:
a: 66.5Å b: 120.261Å c: 133.26Å
α: 90° β: 90° γ: 90°
R R work R free
0.157 0.156 0.183
Expression system: Escherichia coli