PDBe 5tok

X-ray diffraction
3.8Å resolution

Crystal structure of the RSV F glycoprotein in complex with the neutralizing single-domain antibody F-VHH-L66

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fusion glycoprotein F0 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 550 amino acids
Theoretical weight: 61.05 KDa
Source organism: Human orthopneumovirus
Expression system: Homo sapiens
UniProt:
  • Canonical: P03420 (Residues: 1-516; Coverage: 89%)
Gene name: F
Single-domain antibody F-VHH-L66 Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 131 amino acids
Theoretical weight: 14.36 KDa
Source organism: Lama glama
Expression system: Komagataella phaffii GS115

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P3121
Unit cell:
a: 138.89Å b: 138.89Å c: 221.902Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.249 0.248 0.286
Expression systems:
  • Homo sapiens
  • Komagataella phaffii GS115