PDBe 5toj

X-ray diffraction
3.3Å resolution

Crystal structure of the RSV F glycoprotein in complex with the neutralizing single-domain antibody F-VHH-4


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fusion glycoprotein F0 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 550 amino acids
Theoretical weight: 61.05 KDa
Source organism: Human orthopneumovirus
Expression system: Homo sapiens
  • Canonical: P03420 (Residues: 1-516; Coverage: 89%)
Gene name: F
Single-domain antibody F-VHH-4 Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 131 amino acids
Theoretical weight: 14.44 KDa
Source organism: Lama glama
Expression system: Komagataella phaffii GS115

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P3221
Unit cell:
a: 173.189Å b: 173.189Å c: 153.301Å
α: 90° β: 90° γ: 120°
R R work R free
0.187 0.184 0.234
Expression systems:
  • Homo sapiens
  • Komagataella phaffii GS115