PDBe 5tjy

X-ray diffraction
2.4Å resolution

Structure of 4-Hydroxy-tetrahydrodipicolinate Reductase from Mycobacterium tuberculosis with 2,6 Pyridine Dicarboxylic Acid and NADH

Released:
Entry authors: Mank N, Arnette K, Klapper V, Chruszcz M

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
4-hydroxy-tetrahydrodipicolinate reductase Chain: A
Molecule details ›
Chain: A
Length: 245 amino acids
Theoretical weight: 25.68 KDa
Source organism: Mycobacterium tuberculosis H37Ra
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A5U6C6 (Residues: 1-244; Coverage: 100%)
Gene names: MRA_2798, dapB
Sequence domains:

Ligands and Environments


Cofactor: Ligand NAI 1 x NAI

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P6222
Unit cell:
a: 66.421Å b: 66.421Å c: 249.363Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.148 0.146 0.195
Expression system: Escherichia coli BL21(DE3)