PDBe 5t5w

X-ray diffraction
2.85Å resolution

Structure of an affinity matured lambda-IFN/IFN-lambdaR1/IL-10Rbeta receptor complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Interferon lambda-3 Chain: C
Molecule details ›
Chain: C
Length: 176 amino acids
Theoretical weight: 19.91 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q8IZI9 (Residues: 34-195; Coverage: 93%)
Gene names: IFNL3, IL28B, IL28C, ZCYTO22
Sequence domains: Interleukin-28A
Interferon lambda receptor 1 Chain: B
Molecule details ›
Chain: B
Length: 218 amino acids
Theoretical weight: 24.7 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8IU57 (Residues: 21-226; Coverage: 41%)
  • Best match: Q8IU57-4 (Residues: 21-223)
Gene names: IFNLR1, IL28RA, LICR2
Interleukin-10 receptor subunit beta Chain: A
Molecule details ›
Chain: A
Length: 214 amino acids
Theoretical weight: 25.05 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q08334 (Residues: 19-220; Coverage: 66%)
Gene names: CRFB4, D21S58, D21S66, IL10RB
Sequence domains: Interferon-alpha/beta receptor, fibronectin type III

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P3121
Unit cell:
a: 106.79Å b: 106.79Å c: 129.71Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.201 0.198 0.253
Expression systems:
  • Trichoplusia ni
  • Homo sapiens