› 5t0r

X-ray diffraction
1.95Å resolution

Synaptotagmin 1 C2A domain, cadmium-bound

Released:
DOI: 10.2210/pdb5t0r/pdb
PDB entry 5t0r coloured by chain, front view.
PDB entry 5t0r coloured by chain, side view.
PDB entry 5t0r coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Non-Native Metal Ion Reveals the Role of Electrostatics in Synaptotagmin 1-Membrane Interactions.
Katti S, Nyenhuis SB, Her B, Srivastava AK, Taylor AB, Hart PJ, Cafiso DS, Igumenova TI
Biochemistry 56 3283-3295 (2017)
PMID: 28574251

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155425 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Synaptotagmin-1 Chain: A
Molecule details ›
Chain: A
Length: 126 amino acids
Theoretical weight: 14.53 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P46096 (Residues: 140-265; Coverage: 30%)
Gene name: Syt1
Sequence domains: C2 domain
Structure domains: C2 domain

Ligands and Environments

1 bound ligand:
Ligand CD 1 x CD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P212121
Unit cell:
a: 28.064Å b: 63.276Å c: 76.143Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.186 0.229
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Cell organelles as targets of mammalian cadmium toxicity.
Lee et al. (2020)
8 other articles

2 mentions without citation

Non-Native Metal Ion Reveals the Role of Electrostatics in Synaptotagmin 1-Membrane Interactions.
Katti et al. (2017)
1 more