5sw9

X-ray diffraction
2.85Å resolution

The structure of the PP2A B56 subunit RepoMan complex

Released:
Source organism: Homo sapiens
Primary publication:
Expanding the PP2A Interactome by Defining a B56-Specific SLiM.
Structure 24 2174-2181 (2016)
PMID: 27998540

Function and Biology Details

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Chain: A
Molecule details ›
Chain: A
Length: 355 amino acids
Theoretical weight: 41.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13362 (Residues: 31-380; Coverage: 67%)
  • Best match: Q13362-4 (Residues: 86-435)
Gene names: KIAA0044, PPP2R5C
Structure domains: Leucine-rich Repeat Variant
Cell division cycle-associated protein 2 Chain: B
Molecule details ›
Chain: B
Length: 21 amino acids
Theoretical weight: 2.41 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q69YH5 (Residues: 581-601; Coverage: 2%)
Gene name: CDCA2

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P212121
Unit cell:
a: 53.598Å b: 108.959Å c: 120.065Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.198 0.227
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided