PDBe 5sve

X-ray diffraction
2.6Å resolution

Structure of Calcineurin in complex with NFATc1 LxVP peptide

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Chain: A
Molecule details ›
Chain: A
Length: 370 amino acids
Theoretical weight: 42.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q08209 (Residues: 1-370; Coverage: 71%)
Gene names: CALNA, CNA, PPP3CA
Sequence domains: Calcineurin-like phosphoesterase
Calcineurin subunit B type 1 Chain: B
Molecule details ›
Chain: B
Length: 170 amino acids
Theoretical weight: 19.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P63098 (Residues: 1-170; Coverage: 100%)
Gene names: CNA2, CNB, PPP3R1
Sequence domains:
Nuclear factor of activated T-cells, cytoplasmic 1 Chain: C
Molecule details ›
Chain: C
Length: 18 amino acids
Theoretical weight: 2.19 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O95644 (Residues: 384-400; Coverage: 2%)
Gene names: NFAT2, NFATC, NFATC1

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P212121
Unit cell:
a: 57.679Å b: 106.046Å c: 111.913Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.195 0.239
Expression systems:
  • Escherichia coli
  • Not provided