PDBe 5ooh

X-ray diffraction
1.2Å resolution

Human biliverdin IX beta reductase: NADP/Erythrosin extra bluish ternary complex

Released:

Function and Biology Details

Reactions catalysed:
Bilirubin + NAD(P)(+) = biliverdin + NAD(P)H
Reduced riboflavin + NADP(+) = riboflavin + NADPH
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Flavin reductase (NADPH) Chain: A
Molecule details ›
Chain: A
Length: 206 amino acids
Theoretical weight: 22.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P30043 (Residues: 1-206; Coverage: 100%)
Gene names: BLVRB, FLR
Sequence domains: NAD(P)H-binding

Ligands and Environments


Cofactor: Ligand NAP 1 x NAP
2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P212121
Unit cell:
a: 49.263Å b: 40.259Å c: 107.231Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.123 0.122 0.147
Expression system: Escherichia coli