5oeg

X-ray diffraction
3.15Å resolution

Molecular tweezers modulate 14-3-3 protein-protein interactions

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
14-3-3 protein sigma Chain: A
Molecule details ›
Chain: A
Length: 235 amino acids
Theoretical weight: 26.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P31947 (Residues: 1-231; Coverage: 93%)
Gene names: HME1, SFN
Sequence domains: 14-3-3 protein

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: C222
Unit cell:
a: 63.5Å b: 154.71Å c: 77.01Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 0.181 0.266
Expression system: Escherichia coli