X-ray diffraction
1.17Å resolution

Crystal structure of the c-Src-SH3 domain Q128R mutant in complex with the high affinity peptide APP12

Entry author: Camara-Artigas A

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Proto-oncogene tyrosine-protein kinase Src Chain: A
Molecule details ›
Chain: A
Length: 61 amino acids
Theoretical weight: 6.93 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
  • Canonical: P00523 (Residues: 85-141; Coverage: 11%)
Gene name: SRC
Sequence domains: SH3 domain
APP12 Chain: B
Molecule details ›
Chain: B
Length: 13 amino acids
Theoretical weight: 1.41 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: C2
Unit cell:
a: 65.8Å b: 32.84Å c: 31.58Å
α: 90° β: 104.39° γ: 90°
R R work R free
0.12 0.119 0.141
Expression systems:
  • Escherichia coli
  • Not provided