PDBe 5o2t

X-ray diffraction
2.19Å resolution

Human KRAS in complex with darpin K27

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
darpin 55 Chain: B
Molecule details ›
Chain: B
Length: 187 amino acids
Theoretical weight: 20.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
GTPase KRas, N-terminally processed Chain: A
Molecule details ›
Chain: A
Length: 169 amino acids
Theoretical weight: 19.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01116 (Residues: 1-166; Coverage: 88%)
  • Best match: P01116-2 (Residues: 1-166)
Gene names: KRAS, KRAS2, RASK2
Sequence domains: Ras family

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: R3
Unit cell:
a: 112.83Å b: 112.83Å c: 66.77Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.184 0.182 0.229
Expression system: Escherichia coli