X-ray diffraction
4.19Å resolution

Crystal Structure of Human Pro-myostatin Precursor at 4.2 A Resolution with Experimental Phases from SeMet labelling


Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Growth/differentiation factor 8 Chains: A, B
Molecule details ›
Chains: A, B
Length: 335 amino acids
Theoretical weight: 38.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: O14793 (Residues: 43-375; Coverage: 95%)
Gene names: GDF8, MSTN
Sequence domains: Transforming growth factor beta like domain

Ligands and Environments

No bound ligands
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: I23
Unit cell:
a: 196.83Å b: 196.83Å c: 196.83Å
α: 90° β: 90° γ: 90°
R R work R free
0.276 0.274 0.301
Expression system: Escherichia coli BL21(DE3)