› 5nqu

X-ray diffraction
1.8Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-160567 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Tubulin alpha-1B chain Chain: A
Molecule details ›
Chain: A
Length: 451 amino acids
Theoretical weight: 50.2 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P81947 (Residues: 1-451; Coverage: 100%)
Sequence domains:
Structure domains:
Tubulin beta-2B chain Chain: B
Molecule details ›
Chain: B
Length: 445 amino acids
Theoretical weight: 50 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q6B856 (Residues: 1-445; Coverage: 100%)
Gene name: TUBB2B
Sequence domains:
Structure domains:
Designed Ankyrin Repeat Protein (DARPIN) D1 Chain: F
Molecule details ›
Chain: F
Length: 169 amino acids
Theoretical weight: 18.07 KDa
Source organism: synthetic construct
Expression system: Escherichia coli
Structure domains: Ankyrin repeat-containing domain

Ligands and Environments

3 bound ligands:
Ligand GTP 1 x GTP
Ligand MG 1 x MG
Ligand GDP 1 x GDP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 74.04Å b: 91.74Å c: 82.645Å
α: 90° β: 97.46° γ: 90°
R-values:
R R work R free
0.177 0.176 0.207
Expression system: Escherichia coli

Quick links

Citations

13 review citations

International Union of Basic and Clinical Pharmacology. CXII: Adenosine Receptors: A Further Update.
IJzerman et al. (2022)
12 more

7 mentions without citation

Proteinaceous Regulators and Inhibitors of Protein Tyrosine Phosphatases.
Hendriks et al. (2018)
6 more