PDBe 5nqh

X-ray diffraction
2.6Å resolution

Structure of the human Fe65-PTB2 homodimer

Released:
Source organism: Homo sapiens

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amyloid-beta A4 precursor protein-binding family B member 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 140 amino acids
Theoretical weight: 15.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00213 (Residues: 534-667; Coverage: 19%)
Gene names: APBB1, FE65, RIR
Sequence domains: Phosphotyrosine interaction domain (PTB/PID)

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P21
Unit cell:
a: 56.578Å b: 104.279Å c: 60.578Å
α: 90° β: 112.04° γ: 90°
R-values:
R R work R free
0.195 0.193 0.24
Expression system: Escherichia coli