PDBe 5no6

X-ray diffraction
2.88Å resolution

TEAD4-HOXB13 complex bound to DNA

Released:
Source organism: Homo sapiens
Entry authors: Morgunova E, Jolma A, Yin Y, Popov A, Taipale J

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
2 distinct DNA molecules
Macromolecules (4 distinct):
Homeobox protein Hox-B13 Chains: A, B
Molecule details ›
Chains: A, B
Length: 62 amino acids
Theoretical weight: 7.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q92826 (Residues: 217-278; Coverage: 22%)
Gene name: HOXB13
Sequence domains: Homeodomain
Transcriptional enhancer factor TEF-3 Chains: I, N
Molecule details ›
Chains: I, N
Length: 73 amino acids
Theoretical weight: 8.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15561 (Residues: 40-112; Coverage: 17%)
Gene names: RTEF1, TCF13L1, TEAD4, TEF3
DNA Chains: C, D
Molecule details ›
Chains: C, D
Length: 18 nucleotides
Theoretical weight: 5.47 KDa
DNA Chains: E, F
Molecule details ›
Chains: E, F
Length: 18 nucleotides
Theoretical weight: 5.56 KDa

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Unit cell:
a: 82.659Å b: 56.674Å c: 144.993Å
α: 90° β: 93.81° γ: 90°
R-values:
R R work R free
0.244 0.24 0.317
Expression system: Escherichia coli BL21(DE3)