5n5w

X-ray diffraction
1.37Å resolution

14-3-3 sigma in complex with TAZ pS89 peptide and fragment NV3

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
14-3-3 protein sigma Chain: A
Molecule details ›
Chain: A
Length: 236 amino acids
Theoretical weight: 26.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P31947 (Residues: 1-231; Coverage: 93%)
Gene names: HME1, SFN
Sequence domains: 14-3-3 protein
WW domain-containing transcription regulator protein 1 Chain: P
Molecule details ›
Chain: P
Length: 10 amino acids
Theoretical weight: 1.15 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9GZV5 (Residues: 86-95; Coverage: 3%)
Gene names: TAZ, WWTR1

Ligands and Environments


1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, DESY BEAMLINE P11
Spacegroup: C2221
Unit cell:
a: 81.293Å b: 112.286Å c: 62.506Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.145 0.144 0.165
Expression systems:
  • Escherichia coli
  • Not provided