PDBe 5l6n

X-ray diffraction
1.63Å resolution

Disulfated madanin-thrombin complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Thrombin light chain Chain: L
Molecule details ›
Chain: L
Length: 36 amino acids
Theoretical weight: 4.1 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00734 (Residues: 328-363; Coverage: 6%)
Gene name: F2
Thrombin heavy chain Chain: H
Molecule details ›
Chain: H
Length: 259 amino acids
Theoretical weight: 29.78 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00734 (Residues: 364-622; Coverage: 43%)
Gene name: F2
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Inhibitor_I53 domain-containing protein Chain: I
Molecule details ›
Chain: I
Length: 35 amino acids
Theoretical weight: 4.03 KDa
Source organism: Haemaphysalis longicornis
Expression system: Not provided
UniProt:
  • Canonical: Q86FP9 (Residues: 39-73; Coverage: 58%)

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P212121
Unit cell:
a: 44.546Å b: 80.238Å c: 91.369Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.168 0.167 0.198
Expression system: Not provided