5kcj

X-ray diffraction
2.09Å resolution

Structure of the human GluN1/GluN2A LBD in complex with GNE6901

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Glutamate receptor ionotropic, NMDA 2A Chain: A
Molecule details ›
Chain: A
Length: 285 amino acids
Theoretical weight: 31.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q12879 (Residues: 401-539, 661-802; Coverage: 20%)
Gene names: GRIN2A, NMDAR2A
Structure domains: Periplasmic binding protein-like II
Glutamate receptor ionotropic, NMDA 1 Chain: B
Molecule details ›
Chain: B
Length: 293 amino acids
Theoretical weight: 33.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q05586 (Residues: 394-544, 663-800; Coverage: 31%)
Gene names: GRIN1, NMDAR1
Structure domains: Periplasmic binding protein-like II

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P212121
Unit cell:
a: 54.41Å b: 89.73Å c: 124.7Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.181 0.225
Expression system: Escherichia coli