PDBe 5jms

X-ray diffraction
2.3Å resolution

Crystal structure of TgCDPK1 bound to CGP060476

Released:
Source organism: Toxoplasma gondii
Entry authors: El Bakkouri M, Walker JR, Loppnau P, Graslund S, Bountra C, Arrowsmith CH, Edwards AM, Hui R, Lovato DV, Structural Genomics Consortium (SGC)

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calmodulin-domain protein kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 525 amino acids
Theoretical weight: 59.53 KDa
Source organism: Toxoplasma gondii
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BJF5 (Residues: 1-507; Coverage: 100%)
Gene name: CDPK1
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P21
Unit cell:
a: 48.169Å b: 72.75Å c: 65.276Å
α: 90° β: 98.62° γ: 90°
R-values:
R R work R free
0.226 0.224 0.264
Expression system: Escherichia coli