5jej

X-ray diffraction
2Å resolution

Phosphorylated STING in complex with IRF-3 CTD

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Stimulator of interferon genes protein Chains: C, D, E
Molecule details ›
Chains: C, D, E
Length: 39 amino acids
Theoretical weight: 4.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q86WV6 (Residues: 342-379; Coverage: 10%)
Gene names: ERIS, MITA, STING, TMEM173
Interferon regulatory factor 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 242 amino acids
Theoretical weight: 26.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14653 (Residues: 189-427; Coverage: 56%)
Gene name: IRF3
Sequence domains: Interferon-regulatory factor 3
Structure domains: Tumour Suppressor Smad4

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P2
Unit cell:
a: 64.076Å b: 56.401Å c: 75.548Å
α: 90° β: 104.64° γ: 90°
R-values:
R R work R free
0.18 0.176 0.237
Expression systems:
  • Escherichia coli BL21(DE3)
  • Escherichia coli