X-ray diffraction
2.49Å resolution

A new binding site outside the canonical PDZ domain determines the specific interaction between Shank and SAPAP and their function


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
SH3 and multiple ankyrin repeat domains protein 3 Chains: A, C
Molecule details ›
Chains: A, C
Length: 139 amino acids
Theoretical weight: 15.57 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q4ACU6 (Residues: 533-665; Coverage: 8%)
Gene names: Kiaa1650, Prosap2, Shank3
Sequence domains: PDZ domain
Disks large-associated protein 3 Chains: B, D
Molecule details ›
Chains: B, D
Length: 15 amino acids
Theoretical weight: 1.72 KDa
Source organism: Mus musculus
Expression system: Not provided
  • Canonical: Q6PFD5 (Residues: 963-977; Coverage: 2%)
Gene names: Dap3, Dlgap3

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P3112
Unit cell:
a: 72.824Å b: 72.824Å c: 116.36Å
α: 90° β: 90° γ: 120°
R R work R free
0.186 0.183 0.251
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided