5iy5

X-ray diffraction
2Å resolution

Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
Non-polymer only tetradecamer (preferred)
Entry contents:
14 distinct polypeptide molecules
Macromolecules (14 distinct):
Cytochrome c oxidase subunit 1 Chains: A, N
Molecule details ›
Chains: A, N
Length: 514 amino acids
Theoretical weight: 57.09 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00396 (Residues: 1-514; Coverage: 100%)
Gene names: COI, COXI, MT-CO1, MTCO1
Sequence domains: Cytochrome C and Quinol oxidase polypeptide I
Structure domains: Cytochrome c oxidase-like, subunit I domain
Cytochrome c oxidase subunit 2 Chains: B, O
Molecule details ›
Chains: B, O
Length: 227 amino acids
Theoretical weight: 26.07 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P68530 (Residues: 1-227; Coverage: 100%)
Gene names: COII, COX2, COXII, MT-CO2, MTCO2
Sequence domains:
Structure domains:
Cytochrome c oxidase subunit 3 Chains: C, P
Molecule details ›
Chains: C, P
Length: 259 amino acids
Theoretical weight: 29.73 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00415 (Residues: 3-261; Coverage: 99%)
Gene names: COIII, COXIII, MT-CO3, MTCO3
Sequence domains: Cytochrome c oxidase subunit III
Structure domains:
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial Chains: D, Q
Molecule details ›
Chains: D, Q
Length: 144 amino acids
Theoretical weight: 16.91 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00423 (Residues: 26-169; Coverage: 85%)
Gene names: COX4, COX4I1
Sequence domains: Cytochrome c oxidase subunit IV
Structure domains: Cytochrome c oxidase subunit IV
Cytochrome c oxidase subunit 5A, mitochondrial Chains: E, R
Molecule details ›
Chains: E, R
Length: 105 amino acids
Theoretical weight: 12.08 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00426 (Residues: 48-152; Coverage: 69%)
Gene name: COX5A
Structure domains: Cytochrome c oxidase, subunit Va/VI
Cytochrome c oxidase subunit 5B, mitochondrial Chains: F, S
Molecule details ›
Chains: F, S
Length: 98 amino acids
Theoretical weight: 10.68 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00428 (Residues: 32-129; Coverage: 76%)
Gene name: COX5B
Structure domains: Cytochrome c oxidase, subunit Vb
Cytochrome c oxidase subunit 6A2, mitochondrial Chains: G, T
Molecule details ›
Chains: G, T
Length: 84 amino acids
Theoretical weight: 9.53 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P07471 (Residues: 13-96; Coverage: 87%)
Gene names: COX6A, COX6A2
Structure domains: Cytochrome c oxidase, subunit VIa
Cytochrome c oxidase subunit 6B1 Chains: H, U
Molecule details ›
Chains: H, U
Length: 79 amino acids
Theoretical weight: 9.41 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00429 (Residues: 8-86; Coverage: 92%)
Gene names: COX6B, COX6B1
Sequence domains: Cytochrome oxidase c subunit VIb
Structure domains: Cytochrome c oxidase, subunit VIb
Cytochrome c oxidase subunit 6C Chains: I, V
Molecule details ›
Chains: I, V
Length: 73 amino acids
Theoretical weight: 8.54 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P04038 (Residues: 2-74; Coverage: 99%)
Gene name: COX6C
Sequence domains: Cytochrome c oxidase subunit VIc
Structure domains: Mitochondrial cytochrome c oxidase subunit VIc/VIIs
Cytochrome c oxidase subunit 7A1, mitochondrial Chains: J, W
Molecule details ›
Chains: J, W
Length: 58 amino acids
Theoretical weight: 6.55 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P07470 (Residues: 22-79; Coverage: 73%)
Gene names: COX7A, COX7A1, COX7AH
Sequence domains: Cytochrome c oxidase subunit VII
Structure domains: Cytochrome c oxidase, subunit VIIa
Cytochrome c oxidase subunit 7B, mitochondrial Chains: K, X
Molecule details ›
Chains: K, X
Length: 49 amino acids
Theoretical weight: 5.44 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P13183 (Residues: 30-78; Coverage: 61%)
Gene name: COX7B
Structure domains: Cytochrome C Oxidase, chain K
Cytochrome c oxidase subunit 7C, mitochondrial Chains: L, Y
Molecule details ›
Chains: L, Y
Length: 46 amino acids
Theoretical weight: 5.36 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00430 (Residues: 18-63; Coverage: 73%)
Gene names: COX7C, COX7CP1
Structure domains: Cytochrome c oxidase subunit VIIc
Cytochrome c oxidase subunit 8B, mitochondrial Chains: M, Z
Molecule details ›
Chains: M, Z
Length: 43 amino acids
Theoretical weight: 4.74 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P10175 (Residues: 25-67; Coverage: 61%)
Gene names: COX8B, COX8H
Sequence domains: Cytochrome oxidase c subunit VIII
Structure domains: Cytochrome c oxidase, subunit 8
Cytochrome c Chains: 1, 2
Molecule details ›
Chains: 1, 2
Length: 105 amino acids
Theoretical weight: 11.75 KDa
Source organism: Equus caballus
UniProt:
  • Canonical: P00004 (Residues: 2-105; Coverage: 99%)
Gene names: CYC, CYCS
Sequence domains: Cytochrome c
Structure domains: Cytochrome c-like domain

Ligands and Environments

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: P21
Unit cell:
a: 113.29Å b: 183.872Å c: 148.929Å
α: 90° β: 102.12° γ: 90°
R-values:
R R work R free
0.169 0.166 0.207