PDBe 5io1

X-ray diffraction
3.34Å resolution

CRYSTAL STRUCTURE OF RECOMBINANT HUMAN Z ALPHA-1-ANTITRYPSIN

Released:
Source organism: Homo sapiens
Primary publication:
Molecular Mechanism of Z α1-Antitrypsin Deficiency.
OpenAccess logo J. Biol. Chem. 291 15674-86 (2016)
PMID: 27246852

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-1-antitrypsin Chains: A, B
Molecule details ›
Chains: A, B
Length: 398 amino acids
Theoretical weight: 45.01 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P01009 (Residues: 29-418; Coverage: 99%)
  • Best match: P01009-2 (Residues: 29-355)
Gene names: AAT, PI, PRO0684, PRO2209, SERPINA1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.2
Spacegroup: P21
Unit cell:
a: 74.138Å b: 53.675Å c: 110.144Å
α: 90° β: 96.88° γ: 90°
R-values:
R R work R free
0.218 0.215 0.275
Expression system: Drosophila melanogaster