5hvz

X-ray diffraction
2Å resolution

Crystal structure of smAKAP AKB domain bound RIa dimerization/docking (D/D) complex at 2.0 A resolution

Released:

Function and Biology Details

Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed Chains: A, B
Molecule details ›
Chains: A, B
Length: 50 amino acids
Theoretical weight: 6.01 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00514 (Residues: 13-62; Coverage: 13%)
Gene name: PRKAR1A
Sequence domains: Regulatory subunit of type II PKA R-subunit
Structure domains: cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
Small membrane A-kinase anchor protein Chain: C
Molecule details ›
Chain: C
Length: 24 amino acids
Theoretical weight: 2.79 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9BSF0 (Residues: 56-79; Coverage: 25%)
Gene name: C2orf88

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P212121
Unit cell:
a: 37.511Å b: 55.737Å c: 57.268Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.21 0.241
Expression systems:
  • Escherichia coli
  • Not provided