X-ray diffraction
2.29Å resolution

Gp41-targeting HIV-1 fusion inhibitors with helical Ile-Asp-Leu tail


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Transmembrane protein gp41 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 75 amino acids
Theoretical weight: 8.64 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
  • Canonical: P04578 (Residues: 546-653; Coverage: 8%)
Gene name: env
Structure domains: Helix Hairpins

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P21
Unit cell:
a: 42.449Å b: 114.471Å c: 42.936Å
α: 90° β: 91.8° γ: 90°
R R work R free
0.219 0.214 0.263
Expression system: Escherichia coli