PDBe 5grj

X-ray diffraction
3.21Å resolution

Crystal structure of human PD-L1 with monoclonal antibody avelumab

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
avelumab H chain Chain: H
Molecule details ›
Chain: H
Length: 120 amino acids
Theoretical weight: 13.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins
avelumab L chain Chain: L
Molecule details ›
Chain: L
Length: 110 amino acids
Theoretical weight: 11.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins
Programmed cell death 1 ligand 1 Chain: A
Molecule details ›
Chain: A
Length: 221 amino acids
Theoretical weight: 25.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NZQ7 (Residues: 18-238; Coverage: 81%)
Gene names: B7H1, CD274, PDCD1L1, PDCD1LG1, PDL1
Sequence domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: C2
Unit cell:
a: 120.87Å b: 98.151Å c: 62.036Å
α: 90° β: 108.43° γ: 90°
R-values:
R R work R free
0.205 0.204 0.238
Expression system: Escherichia coli