5fo8

X-ray diffraction
2.4Å resolution

Crystal Structure of Human Complement C3b in Complex with MCP (CCP1-4)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Complement C3 beta chain Chain: A
Molecule details ›
Chain: A
Length: 645 amino acids
Theoretical weight: 71.39 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01024 (Residues: 23-667; Coverage: 39%)
Gene names: C3, CPAMD1
Sequence domains:
Structure domains:
Complement C3b alpha' chain Chain: B
Membrane cofactor protein Chain: C
Molecule details ›
Chain: C
Length: 252 amino acids
Theoretical weight: 28.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P15529 (Residues: 35-286; Coverage: 70%)
Gene names: CD46, MCP, MIC10
Sequence domains: Sushi repeat (SCR repeat)
Structure domains: Complement Module, domain 1

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Unit cell:
a: 82.83Å b: 130.63Å c: 233.83Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.188 0.219
Expression system: Escherichia coli