PDBe 5fhc

X-ray diffraction
6.7Å resolution

Crystal Structure of Protective Human Antibodies 100 and 114 in Complex with Ebola Virus Fusion Glycoprotein (GP)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
GP2 Chain: J
Molecule details ›
Chain: J
Length: 98 amino acids
Theoretical weight: 10.97 KDa
Source organism: Ebola virus - Mayinga, Zaire, 1976
Expression system: Homo sapiens
UniProt:
  • Canonical: Q05320 (Residues: 502-599; Coverage: 15%)
Gene name: GP
GP1 Chain: K
Molecule details ›
Chain: K
Length: 322 amino acids
Theoretical weight: 36.32 KDa
Source organism: Ebola virus - Mayinga, Zaire, 1976
Expression system: Homo sapiens
UniProt:
  • Canonical: Q05320 (Residues: 1-308, 490-501; Coverage: 45%)
Gene name: GP
Antibody 100 Fab heavy chain Chain: A
Molecule details ›
Chain: A
Length: 227 amino acids
Theoretical weight: 24.23 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Antibody 100 Fab light chain Chain: B
Molecule details ›
Chain: B
Length: 207 amino acids
Theoretical weight: 22.26 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Antibody 114 Fab light chain Chain: L
Molecule details ›
Chain: L
Length: 212 amino acids
Theoretical weight: 22.94 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Antibody 114 Fab heavy chain Chain: H
Molecule details ›
Chain: H
Length: 220 amino acids
Theoretical weight: 23.2 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: R32
Unit cell:
a: 169.67Å b: 169.67Å c: 376.99Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.265 0.26 0.343
Expression system: Homo sapiens