PDBe 5fbv

X-ray diffraction
3.28Å resolution

PI4KB in complex with Rab11 and the MI364 Inhibitor

Released:
Source organism: Homo sapiens
Entry authors: Chalupska D, Mejdrova I, Nencka R, Boura E

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ras-related protein Rab-11A Chain: B
Molecule details ›
Chain: B
Length: 221 amino acids
Theoretical weight: 24.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62491 (Residues: 1-216; Coverage: 100%)
Gene names: RAB11, RAB11A
Sequence domains: Ras family
Phosphatidylinositol 4-kinase beta Chain: A
Molecule details ›
Chain: A
Length: 572 amino acids
Theoretical weight: 65.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UBF8 (Residues: 128-799; Coverage: 70%)
Gene names: PI4KB, PIK4CB
Sequence domains: Phosphatidylinositol 3- and 4-kinase

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P212121
Unit cell:
a: 48.536Å b: 102.782Å c: 186.141Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.239 0.237 0.281
Expression system: Escherichia coli