X-ray diffraction
2.8Å resolution

Structure of MAPK14 with bound the KIM domain of the Toxoplasma protein GRA24


Function and Biology Details

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Mitogen-activated protein kinase 14 Chains: A, B
Molecule details ›
Chains: A, B
Length: 360 amino acids
Theoretical weight: 41.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q16539 (Residues: 1-360; Coverage: 100%)
Gene names: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, SAPK2A
Sequence domains: Protein kinase domain
Structure domains:
Putative transmembrane protein Chains: C, D
Molecule details ›
Chains: C, D
Length: 16 amino acids
Theoretical weight: 1.81 KDa
Source organism: Toxoplasma gondii
Expression system: Not provided
  • Canonical: B6KJB6 (Residues: 440-455; Coverage: 3%)
Gene names: BN1205_025320, TGVEG_230180

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P1
Unit cell:
a: 52.091Å b: 61.9Å c: 75.671Å
α: 105.62° β: 96.31° γ: 114.65°
R R work R free
0.223 0.219 0.29
Expression systems:
  • Escherichia coli
  • Not provided