X-ray diffraction
3.1Å resolution

Human Plasma Coagulation FXI with peptide LP2


Function and Biology Details

Reaction catalysed:
Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.
Cellular component:

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Coagulation factor XI Chain: A
Molecule details ›
Chain: A
Length: 606 amino acids
Theoretical weight: 67.99 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
  • Canonical: P03951 (Residues: 20-625; Coverage: 100%)
Gene name: F11
Sequence domains:
Structure domains:
LP2 Chain: B
Molecule details ›
Chain: B
Length: 6 amino acids
Theoretical weight: 751 Da
Source organism: Homo sapiens
Expression system: synthetic construct

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P43212
Unit cell:
a: 81.065Å b: 81.065Å c: 253.084Å
α: 90° β: 90° γ: 90°
R R work R free
0.194 0.189 0.274
Expression systems:
  • Cricetulus griseus
  • synthetic construct