X-ray diffraction
1.5Å resolution

Crystal structure of mouse CTLA-4

Source organism: Mus musculus
Entry authors: Fedorov AA, Fedorov EV, SAMANTA D, Bonanno JB, Almo SC

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Cytotoxic T-lymphocyte protein 4 Chain: A
Molecule details ›
Chain: A
Length: 117 amino acids
Theoretical weight: 12.93 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
  • Canonical: P09793 (Residues: 38-154; Coverage: 62%)
Gene names: Cd152, Ctla4
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: C2
Unit cell:
a: 47.538Å b: 36.598Å c: 65.149Å
α: 90° β: 105.13° γ: 90°
R R work R free
0.181 0.18 0.203
Expression system: Escherichia coli