X-ray diffraction
3.36Å resolution

Binary complex of human Polymerase lambda with dCTP

Source organism: Homo sapiens
Primary publication:
Structural Mechanism for the Fidelity Modulation of DNA Polymerase λ.
J. Am. Chem. Soc. (2016)
PMID: 26836966

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
DNA polymerase lambda Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 335 amino acids
Theoretical weight: 37.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q9UGP5 (Residues: 242-575; Coverage: 58%)
Gene name: POLL
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13B1
Spacegroup: P43212
Unit cell:
a: 206.015Å b: 206.015Å c: 114.266Å
α: 90° β: 90° γ: 90°
R R work R free
0.264 0.262 0.297
Expression system: Escherichia coli