X-ray diffraction
1.55Å resolution

Crystal structure of the EGFR kinase domain mutant V924R


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Epidermal growth factor receptor Chains: A, B, X
Molecule details ›
Chains: A, B, X
Length: 330 amino acids
Theoretical weight: 37.62 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P00533 (Residues: 696-1022; Coverage: 28%)
Gene names: EGFR, ERBB, ERBB1, HER1
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: C2
Unit cell:
a: 155.4Å b: 71.837Å c: 76.399Å
α: 90° β: 113.27° γ: 90°
R R work R free
0.176 0.175 0.203
Expression system: Spodoptera frugiperda